Introduction
RU-58841 (also recognized as PSK-3841 or HMR-3841) is a non-steroidal antiandrogen which was formerly investigated for use as a topical treatment for acne, androgenetic alopecia, and hirsutism.The compound is similar in structure to RU-58642 but contains a different aspect-chain. These compounds are related in chemical structure to nilutamide, which is relevant to flutamide, bicalutamide, and enzalutamide. RU-58841 can be synthesized both by creating the hydantoin moiety or by aryl coupling to 5,five-dimethylhydantoin
Fundamental data
| Name | RU 58841 |
| CAS | 154992-24-two |
| Appearance | white powder |
| MF | C17H18F3N3O3 |
| MW | 369.341 |
| Purity | ninety nine%min |
RU 58841 is a specific androgen receptor antagonist or anti-androgen employed as a topical treatment method for pimples, androgenetic alopecia and hirsutism. RU 58841 displays substantial affinity for the hamster prostate and flank organ (F.O.) androgen receptors. In vivo, when topically used, it exerts a potent dose-dependent regression of F.O. area at a dose as minimal as 1 microgram/animal while getting devoid of antiandrogenic exercise on deep accent sex organs and of any effect on testosterone amount up to a hundred micrograms/animal. RU 58841 has a dramatic effect on hair regrowth
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